Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo

[Image: see text] In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in colon epithelial cells in vitro and in vivo. Following 6S treatment of HCT-116 cells, the intracellular GSH/GSSG ratio was initially diminished but was then el...

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Detalhes bibliográficos
Main Authors: Chen, Huadong, Fu, Junsheng, Chen, Hao, Hu, Yuhui, Soroka, Dominique N., Prigge, Justin R., Schmidt, Edward E., Yan, Feng, Major, Michael B., Chen, Xiaoxin, Sang, Shengmin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176387/
https://ncbi.nlm.nih.gov/pubmed/25148906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500211x
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