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Prostaglandin E(2) down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity–breast cancer connection
Obesity increases the risk of hormone receptor–positive breast cancer in postmenopausal women. Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are increased in the breast tissue of obese women. Both prostaglandin E(2) (PGE(2)) and hypoxia-inducible factor 1α (HIF-1α) contribu...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6322870/ https://ncbi.nlm.nih.gov/pubmed/30409902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005866 |
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