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Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs
Molecular tools to target RNA site-specifically allow recoding of RNA information and processing. SNAP-tagged deaminases, guided by a chemically stabilized guideRNA, enable the simultaneous editing of targeted adenosine to inosine in several endogenous transcripts, with high efficiency (up to 90%),...
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| Publicado no: | Nat Methods |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6322650/ https://ncbi.nlm.nih.gov/pubmed/29967493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-018-0017-z |
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