Differences in tumor microenvironments between primary lung tumors and brain metastases in lung cancer patients: therapeutic implications for immune checkpoint inhibitors

BACKGROUND: We aimed to compare intra- and extracranial responses to immune checkpoint inhibitors (ICIs) in lung cancer with brain metastases (BM), and to explore tumor microenvironments of the brain and lungs focusing on the programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) path...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Kim, Ryul, Keam, Bhumsuk, Kim, Sehui, Kim, Miso, Kim, Se Hyun, Kim, Jin Wook, Kim, Yu Jung, Kim, Tae Min, Jeon, Yoon Kyung, Kim, Dong-Wan, Chung, Doo Hyun, Lee, Jong Seok, Heo, Dae Seog
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322302/
https://ncbi.nlm.nih.gov/pubmed/30616523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-5214-8
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