Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents

BACKGROUND: Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) constitute a small KIT/PDGFRA-WT GIST subgroup featuring DNA methylation which, although pervasive, appears nevertheless not randomly distributed. Although often indolent, these tumors are mostly chemorefract...

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Publicado en:Clin Epigenetics
Autores principales: Ricci, Riccardo, Martini, Maurizio, Ravegnini, Gloria, Cenci, Tonia, Milione, Massimo, Lanza, Paola, Pierconti, Francesco, Santini, Donatella, Angelini, Sabrina, Biondi, Alberto, Rosa, Fausto, Alfieri, Sergio, Clemente, Gennaro, Persiani, Roberto, Cassano, Alessandra, Pantaleo, Maria A., Larocca, Luigi M.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322231/
https://ncbi.nlm.nih.gov/pubmed/30616628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0594-9
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