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The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts

Radiotherapy is a primary treatment modality for glioblastomas (GBM). Because DNA-PKcs is a critical factor in the repair of radiation-induced double strand breaks (DSB), this study evaluated the potential of VX-984, a new DNA-PKcs inhibitor, to enhance the radiosensitivity of GBM cells. Treatment o...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cancer Ther
Main Authors: Timme, Cindy R., Rath, Barbara H., O’Neill, John W., Camphausen, Kevin, Tofilon, Philip J.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322200/
https://ncbi.nlm.nih.gov/pubmed/29549168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1267
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