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Selective Editing of Herpes Simplex Virus 1 Enables Interferon Induction and Viral Replication That Destroy Malignant Cells

Oncolytic herpes simplex virus 1 (HSV-1), devoid of the γ(1)34.5 gene, exerts antitumor activities. However, the oncolytic effects differ, ranging from pronounced to little responses. Although viral and host factors are involved, much remains to be deciphered. Here we report that engineered HSV-1 ΔN...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Liu, Xing, He, Bin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6321935/
https://ncbi.nlm.nih.gov/pubmed/30404809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01761-18
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