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Alpha/Beta Interferon and Gamma Interferon Synergize To Inhibit the Replication of Herpes Simplex Virus Type 1

In vivo evidence suggests that T-cell-derived gamma interferon (IFN-γ) can directly inhibit the replication of herpes simplex virus type 1 (HSV-1). However, IFN-γ is a weak inhibitor of HSV-1 replication in vitro. We have found that IFN-γ synergizes with the innate IFNs (IFN-α and -β) to potently in...

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Detalhes bibliográficos
Main Authors: Sainz, Bruno, Halford, William P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136787/
https://ncbi.nlm.nih.gov/pubmed/12388715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.22.11541-11550.2002
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