Hyperglycemia-driven neuroinflammation compromises BBB leading to memory loss in both diabetes mellitus (DM) type 1 and type 2 mouse models

End organ injury in diabetes mellitus (DM) is driven by microvascular compromise (including diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication of DM types 1 and 2; however, its mechanism(s) is(are) not known. We hypothesized that blood brain barrier (BBB) compro...

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Publié dans:Mol Neurobiol
Auteurs principaux: Rom, Slava, Zuluaga-Ramirez, Viviana, Gajghate, Sachin, Seliga, Alecia, Winfield, Malika, Heldt, Nathan A., Kolpakov, Mikhail A., Bashkirova, Yulia V., Sabri, Abdel Karim, Persidsky, Yuri
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320739/
https://ncbi.nlm.nih.gov/pubmed/29974394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1195-5
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