Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles

Cognitive impairment is a well-known complication of diabetes mellitus (DM). Microvascular compromise was described one DM complication. Recently we showed blood brain barrier (BBB) permeability and memory loss are associated with diminution of tight junctions (TJ) in brain endothelium and pericyte...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Rom, Slava, Heldt, Nathan A., Gajghate, Sachin, Seliga, Alecia, Reichenbach, Nancy L., Persidsky, Yuri
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190636/
https://ncbi.nlm.nih.gov/pubmed/32350344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64349-x
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