Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles

Cognitive impairment is a well-known complication of diabetes mellitus (DM). Microvascular compromise was described one DM complication. Recently we showed blood brain barrier (BBB) permeability and memory loss are associated with diminution of tight junctions (TJ) in brain endothelium and pericyte...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rom, Slava, Heldt, Nathan A., Gajghate, Sachin, Seliga, Alecia, Reichenbach, Nancy L., Persidsky, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190636/
https://ncbi.nlm.nih.gov/pubmed/32350344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64349-x
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