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Transcription shapes DNA replication initiation and termination in human cells

Although DNA replication is a fundamental aspect of biology, it is not known what determines where DNA replication starts and stops in the human genome. Here we directly identify and quantitatively compare sites of replication initiation and termination in untransformed human cells. We report that r...

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Pubblicato in:Nat Struct Mol Biol
Autori principali: Chen, Yu-Hung, Keegan, Sarah, Kahli, Malik, Tonzi, Peter, Fenyö, David, Huang, Tony T., Smith, Duncan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320713/
https://ncbi.nlm.nih.gov/pubmed/30598550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0171-0
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