Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces rapid and long-lasting antidepressant effects in major depressive disorder (MDD) patients. (2R,6R)-Hydroxynorketamine [(2R,6R)-HNK], a metabolite of ketamine, is reported to produce rapid antidepressant effects in r...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Fukumoto, Kenichi, Fogaça, Manoela V., Liu, Rong-Jian, Duman, Catharine, Kato, Taro, Li, Xiao-Yuan, Duman, Ronald S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320534/
https://ncbi.nlm.nih.gov/pubmed/30559184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814709116
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