Immunotherapy targeting HPV 16/18 generates potent immune responses in HPV-Associated Head and Neck Cancer

PURPOSE: Clinical responses with programmed death (PD-1) receptor directed antibodies occur in about 20% of patients with advanced head and neck squamous cell cancer (HNSCCa). Viral neoantigens, such as the E6/E7 proteins of HPV16/18 are attractive targets for therapeutic immunization, and offer an...

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Publicat a:Clin Cancer Res
Autors principals: Aggarwal, Charu, Cohen, Roger B., Morrow, Matthew P., Kraynyak, Kimberly A., Sylvester, Albert J., Knoblock, Dawson M., Bauml, Joshua M., Weinstein, Gregory S., Lin, Alexander, Boyer, Jean, Sakata, Lindsay, Tan, Sophie, Anton, Aubrey, Dickerson, Kelsie, Mangrolia, Drishty, Vang, Russell, Dallas, Michael, Oyola, Sandra, Duff, Susan, Esser, Mark, Kumar, Rakesh, Weiner, David, Csiki, Ildiko, Bagarazzi, Mark L.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320307/
https://ncbi.nlm.nih.gov/pubmed/30242022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1763
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