Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways

The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated IC(50) value of 3 µM a...

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Detalhes bibliográficos
Publicado no:Biomol Ther (Seoul)
Main Authors: Han, Xia, Kang, Kyoung Ah, Piao, Mei Jing, Zhen, Ao Xuan, Hyun, Yu Jae, Kim, Hyun Min, Ryu, Yea Seong, Hyun, Jin Won
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Applied Pharmacology 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319547/
https://ncbi.nlm.nih.gov/pubmed/29925224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2018.047
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