N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling

BACKGROUND: Glioblastomas multiforme (GBM) is the most devastating primary intracranial malignancy lacking effective clinical treatments. Notch2 has been established to be a prognostic marker and probably involved in GBM malignant progression. N-acetylcysteine (NAC), a precursor of intracellular glu...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Deng, Jie, Liu, An-Dong, Hou, Guo-Qing, Zhang, Xi, Ren, Kun, Chen, Xuan-Zuo, Li, Shawn S. C., Wu, Yao-Song, Cao, Xuan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319015/
https://ncbi.nlm.nih.gov/pubmed/30606241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-1016-8
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