Notch1 ablation radiosensitizes glioblastoma cells

Broad specific Notch1 inhibitors suppress glioblastoma multiforme (GBM) growth but have significant gastrointestinal toxicities. Here, we examined Notch1 expression in GBM tissue specimens and its correlation with the overall survival (OS) of GBM patients. Furthermore, using the CRISPR/Cas9 system,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Han, Na, Hu, Guangyuan, Shi, Lei, Long, Guoxian, Yang, Lin, Xi, Qingsong, Guo, Qiuyun, Wang, Jianhua, Dong, Zhen, Zhang, Mengxian
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675693/
https://ncbi.nlm.nih.gov/pubmed/29152141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21409
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