Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

In the isolated rat carotid artery, the endocannabinoid anandamide induces endothelium-dependent relaxation via activation of the enzyme sphingosine kinase (SK). This generates sphingosine-1-phosphate (S1P) which can be released from the cell and activates S1P receptors on the endothelium. In anaest...

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Publicat a:Eur J Pharmacol
Autors principals: Greig, Fiona H., Nather, Katrin, Ballantyne, Margaret D., Kazi, Zeshan H., Alganga, Husam, Ewart, Marie-Ann, Zaborska, Karolina E., Fertig, Bracy, Pyne, Nigel J., Pyne, Susan, Kennedy, Simon
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318480/
https://ncbi.nlm.nih.gov/pubmed/30359564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2018.10.027
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