Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

Older patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy. B-cell lymphoma 2 (BCL-2) overexpression is implicated in survival of AML cells and treatment resistance. We report safety and efficacy of venetoclax with decitabine or azacitidine from a large, multicente...

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Bibliographic Details
Published in:Blood
Main Authors: DiNardo, Courtney D., Pratz, Keith, Pullarkat, Vinod, Jonas, Brian A., Arellano, Martha, Becker, Pamela S., Frankfurt, Olga, Konopleva, Marina, Wei, Andrew H., Kantarjian, Hagop M., Xu, Tu, Hong, Wan-Jen, Chyla, Brenda, Potluri, Jalaja, Pollyea, Daniel A., Letai, Anthony
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2019
Subjects:
Plenary Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318429/
https://ncbi.nlm.nih.gov/pubmed/30361262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-08-868752
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