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Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway
REV-ERBα, the NR1D1 (nuclear receptor subfamily 1, group D, member 1) gene product, is a dominant transcriptional silencer that represses the expression of genes involved in numerous physiological functions, including circadian rhythm, inflammation, and metabolism, and plays a crucial role in mainta...
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| Publicado no: | Acta Pharmacol Sin |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6318300/ https://ncbi.nlm.nih.gov/pubmed/29950615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0064-0 |
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