Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

Human immunodeficiency virus 1 (HIV-1) is a life-threatening pathogen that still lacks a curative therapy or vaccine. Despite the reduction in AIDS-related deaths achieved by current antiretroviral therapies, drawbacks including drug resistance and the failure to eradicate infection highlight the ne...

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Udgivet i:Sci Rep
Main Authors: Borrmann, Helene, Davies, Rhianna, Dickinson, Matthew, Pedroza-Pacheco, Isabela, Schilling, Mirjam, Vaughan-Jackson, Alun, Magri, Andrea, James, William, Balfe, Peter, Borrow, Persephone, McKeating, Jane A., Zhuang, Xiaodong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413328/
https://ncbi.nlm.nih.gov/pubmed/32764708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70170-3
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