GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients with Nonalcoholic Fatty Liver Disease

BACKGROUND AND AIMS: De novo lipogenesis is increased in livers of patients with nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase catalyzes the rate-limiting step in this process. We evaluated the safety and efficacy of GS-0976, an inhibitor of acetyl-CoA carboxylase in liver, in a phase...

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Publicat a:Gastroenterology
Autors principals: Loomba, Rohit, Kayali, Zeid, Noureddin, Mazen, Ruane, Peter, Lawitz, Eric J., Bennett, Michael, Wang, Lulu, Harting, Eliza, Tarrant, Jacqueline M., McColgan, Bryan J., Chung, Chuhan, Ray, Adrian S., Subramanian, G. Mani, Myers, Robert P., Middleton, Michael S., Lai, Michelle, Charlton, Michael, Harrison, Stephen A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318218/
https://ncbi.nlm.nih.gov/pubmed/30059671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.07.027
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