Resveratrol and ivacaftor are additive G551D CFTR channel potentiators: Therapeutic implications for cystic fibrosis sinus disease

INTRODUCTION: Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene result in defective Cl(−) transport and cause chronic bacterial infections in the upper and lower airways of cystic fibrosis (CF) patients. Ivacaftor is a CFTR potentiator that improves Cl(−) transport in...

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Publicado no:Int Forum Allergy Rhinol
Main Authors: Cho, Do-Yeon, Zhang, Shaoyan, Lazrak, Ahmed, Grayson, Jessica W., Peña Garcia, Jaime A., Skinner, Daniel F., Lim, Dong Jin, Mackey, Calvin, Banks, Catherine, Matalon, Sadis, Woodworth, Bradford A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318032/
https://ncbi.nlm.nih.gov/pubmed/30152192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alr.22202
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