The Fragile X Mutation Impairs Homeostatic Plasticity in Human Neurons by Blocking Synaptic Retinoic-Acid Signaling

Fragile X syndrome (FXS) is an X-chromosome-linked disease leading to severe intellectual disabilities. FXS is caused by inactivation of the fragile X mental retardation 1 (FMR1) gene, but how FMR1 inactivation induces FXS remains unclear. Using human neurons generated from control and FXS patient-d...

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Publicat a:Sci Transl Med
Autors principals: Zhang, Zhenjie, Marro, Samuele G., Zhang, Yingsha, Arendt, Kristin L., Patzke, Christopher, Zhou, Bo, Fair, Tyler, Yang, Nan, Südhof, Thomas C., Wernig, Marius, Chen, Lu
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317709/
https://ncbi.nlm.nih.gov/pubmed/30068571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aar4338
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