N(6)-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

Internal N(6)-methyladenosine (m(6)A) modification is widespread in messenger RNAs (mRNAs) and catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) and Mettl14. To understand the role of m(6)A in development, we deleted Mettl14 in embryonic neural stem cells (NSCs) in a mouse model...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Wang, Yang, Li, Yue, Yue, Minghui, Wang, Jun, Kumar, Sandeep, Wechsler-Reya, Robert J., Zhang, Zhaolei, Ogawa, Yuya, Kellis, Manolis, Duester, Gregg, Zhao, Jing Crystal
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317335/
https://ncbi.nlm.nih.gov/pubmed/29335608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-017-0057-1
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