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N(6)-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications
Internal N(6)-methyladenosine (m(6)A) modification is widespread in messenger RNAs (mRNAs) and catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) and Mettl14. To understand the role of m(6)A in development, we deleted Mettl14 in embryonic neural stem cells (NSCs) in a mouse model...
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| Udgivet i: | Nat Neurosci |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317335/ https://ncbi.nlm.nih.gov/pubmed/29335608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-017-0057-1 |
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