Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization

BACKGROUND: The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In interphase cells, microtubules play an important role in the delivery of proteins to su...

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Detalhes bibliográficos
Publicado no:Cancer Cell Int
Main Authors: van Vuuren, Rustelle Janse, Botes, Mandie, Jurgens, Tamarin, Joubert, Anna Margaretha, van den Bout, Iman
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317210/
https://ncbi.nlm.nih.gov/pubmed/30622437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0719-4
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