A novel non-sulphamoylated 2-methoxyestradiol derivative causes detachment of breast cancer cells by rapid disassembly of focal adhesions

BACKGROUND: 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application. Therefore, more stable derivatives with potentially improved clinical featur...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell Int
Asıl Yazarlar: Botes, Mandie, Jurgens, Tamarin, Riahi, Zohreh, Visagie, Michelle, Janse van Vuuren, Rustelle, Joubert, Anna Margaretha, van den Bout, Iman
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2018
Konular:
Primary Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245879/
https://ncbi.nlm.nih.gov/pubmed/30479567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-018-0688-7
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