Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells

Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits. Mcl-1 is an anti-apoptotic protein that promotes resistance to paclitaxel in different tumors. Obatoclax, a BH3 mime...

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Bibliografiska uppgifter
I publikationen:Cancers (Basel)
Huvudupphovsmän: Jiménez-Guerrero, Rocío, Gasca, Jessica, Flores, M. Luz, Pérez-Valderrama, Begoña, Tejera-Parrado, Cristina, Medina, Rafael, Tortolero, María, Romero, Francisco, Japón, Miguel A., Sáez, Carmen
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6316685/
https://ncbi.nlm.nih.gov/pubmed/30563080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10120490
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