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Synthesis and Initial In Vivo Evaluation of [(11)C]AZ683—A Novel PET Radiotracer for Colony Stimulating Factor 1 Receptor (CSF1R)
Positron emission tomography (PET) imaging of Colony Stimulating Factor 1 Receptor (CSF1R) is a new strategy for quantifying both neuroinflammation and inflammation in the periphery since CSF1R is expressed on microglia and macrophages. AZ683 has high affinity for CSF1R (K(i) = 8 nM; IC(50) = 6 nM)...
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| Publié dans: | Pharmaceuticals (Basel) |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6316681/ https://ncbi.nlm.nih.gov/pubmed/30551596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph11040136 |
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