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A common molecular logic determines embryonic stem cell self‐renewal and reprogramming

During differentiation and reprogramming, new cell identities are generated by reconfiguration of gene regulatory networks. Here, we combined automated formal reasoning with experimentation to expose the logic of network activation during induction of naïve pluripotency. We find that a Boolean netwo...

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Pubblicato in:EMBO J
Autori principali: Dunn, Sara‐Jane, Li, Meng Amy, Carbognin, Elena, Smith, Austin, Martello, Graziano
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6316172/
https://ncbi.nlm.nih.gov/pubmed/30482756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100003
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