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A common molecular logic determines embryonic stem cell self‐renewal and reprogramming

During differentiation and reprogramming, new cell identities are generated by reconfiguration of gene regulatory networks. Here, we combined automated formal reasoning with experimentation to expose the logic of network activation during induction of naïve pluripotency. We find that a Boolean netwo...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Dunn, Sara‐Jane, Li, Meng Amy, Carbognin, Elena, Smith, Austin, Martello, Graziano
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6316172/
https://ncbi.nlm.nih.gov/pubmed/30482756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100003
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