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SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation
During active DNA demethylation, 5‐methylcytosine (5mC) is oxidized by TET proteins to 5‐formyl‐/5‐carboxylcytosine (5fC/5caC) for replacement by unmethylated C by TDG‐initiated DNA base excision repair (BER). Base excision generates fragile abasic sites (AP‐sites) in DNA and has to be coordinated w...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6315294/ https://ncbi.nlm.nih.gov/pubmed/30523148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899242 |
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