Pharmacological stimulation of NQO1 decreases NADPH levels and ameliorates acute pancreatitis in mice

Reactive oxygen species (ROS) regulates the activation of inflammatory cascades and tissue damage in acute pancreatitis. NADPH oxidase (NOX) is upregulated in pancreatitis and is one of the major enzymes involved in ROS production using NADPH as a general rate-limiting substrate. Dunnione, a well-kn...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Cell Death Dis
Päätekijät: Shen, AiHua, Kim, Hyung-Jin, Oh, Gi-Su, Lee, Su-Bin, Lee, SeungHoon, Pandit, Arpana, Khadka, Dipendra, Sharma, Subham, Kim, Seon Young, Choe, Seong-Kyu, Yang, Sei-Hoon, Cho, Eun-Young, Shim, Hyuk, Park, Raekil, Kwak, Tae Hwan, So, Hong-Seob
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6315021/
https://ncbi.nlm.nih.gov/pubmed/30584237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1252-z
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