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Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity

PURPOSE: Parallel signaling reduces the effects of receptor tyrosine kinase (RTK) targeted therapies in glioma. We hypothesized that inhibition of protein N-linked glycosylation, an endoplasmic reticulum co- and post-translational modification crucial for RTK maturation and activation, could provide...

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Опубликовано в: :Clin Cancer Res
Главные авторы: Baro, Marta, Sambrooks, Cecilia Lopez, Quijano, Amanda, Saltzman, W. Mark, Contessa, Joseph
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314911/
https://ncbi.nlm.nih.gov/pubmed/29967251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0792
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