Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors

Asparagine (N)-linked glycosylation is a post-translational modification essential for the function of complex transmembrane proteins. However, targeting glycosylation for cancer therapy has not been feasible due to generalized effects on all glycoproteins. Here we perform sensitivity screening of 9...

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Vydáno v:Cancer Res
Hlavní autoři: Sambrooks, Cecilia Lopez, Baro, Marta, Quijano, Amanda, Narayan, Azeet, Cui, Wei, Greninger, Patricia, Egan, Regina, Patel, Abhijit, Benes, Cyril H., Saltzman, W. Mark, Contessa, Joseph N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125176/
https://ncbi.nlm.nih.gov/pubmed/30026325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0505
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