IDH3α regulates one-carbon metabolism in glioblastoma

Mutation or transcriptional up-regulation of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) promotes cancer progression through metabolic reprogramming and epigenetic deregulation of gene expression. Here, we demonstrate that IDH3α, a subunit of the IDH3 heterotetramer, is elevated in glioblastom...

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Udgivet i:Sci Adv
Main Authors: May, Jasmine L., Kouri, Fotini M., Hurley, Lisa A., Liu, Juan, Tommasini-Ghelfi, Serena, Ji, Yanrong, Gao, Peng, Calvert, Andrea E., Lee, Andrew, Chandel, Navdeep S., Davuluri, Ramana V., Horbinski, Craig M., Locasale, Jason W., Stegh, Alexander H.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314828/
https://ncbi.nlm.nih.gov/pubmed/30613765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aat0456
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