Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food

Centrally administered glucagon-like peptide 1 (GLP-1) supresses food intake. Here we demonstrate that GLP-1–producing (PPG) neurons in the nucleus tractus solitarii (NTS) are the predominant source of endogenous GLP-1 within the brain. Selective ablation of NTS PPG neurons by viral expression of di...

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Detalles Bibliográficos
Publicado en:Diabetes
Main Authors: Holt, Marie K., Richards, James E., Cook, Daniel R., Brierley, Daniel I., Williams, Diana L., Reimann, Frank, Gribble, Fiona M., Trapp, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2019
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314470/
https://ncbi.nlm.nih.gov/pubmed/30279161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0729
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