Defective anti-polysaccharide IgG vaccine responses in IgA deficient mice

We report that IgA(−/−) mice exhibit specific defects in IgG antibody responses to various polysaccharide vaccines (Francisella tularensis LPS and Pneumovax), but not protein vaccines such as Fluzone. This defect further included responses to polysaccharide-protein conjugate vaccines (Prevnar and Ha...

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Bibliographic Details
Published in:Vaccine
Main Authors: Furuya, Yoichi, Kirimanjeswara, Girish S., Roberts, Sean, Racine, Rachael, Wilson-Welder, Jennifer, Sanfilippo, Alan M, Salmon, Sharon L, Metzger, Dennis W.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314215/
https://ncbi.nlm.nih.gov/pubmed/28774562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.07.071
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