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Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome

Precursor messenger RNA (pre-mRNA) splicing is executed by the spliceosome. In the past 3 years, cryoelectron microscopy (cryo-EM) structures have been elucidated for a majority of the yeast spliceosomal complexes and for a few human spliceosomes. During the splicing reaction, the dynamic spliceosom...

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Vydáno v:Cold Spring Harb Perspect Biol
Hlavní autoři: Yan, Chuangye, Wan, Ruixue, Shi, Yigong
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314064/
https://ncbi.nlm.nih.gov/pubmed/30602541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a032409
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