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HDL Mimetic Peptide 4F Mitigates Aβ-Induced Inhibition of ApoE Secretion and Lipidation in Primary Astrocytes and Microglia
The apolipoprotein (apo) E ε4 allele is the primary genetic risk factor for late-onset Alzheimer’s disease (AD). ApoE in the brain is produced primarily by astrocytes; once secreted from these cells, apoE binds lipids and forms high-density lipoprotein (HDL)-like particles. Accumulation of amyloid-β...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314045/ https://ncbi.nlm.nih.gov/pubmed/30028014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14554 |
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