Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

Background: Alopecia areata (AA) is associated with Interferon- γ (IFN-γ) mediated T-lymphocyte dysfunction and increased circulating Interleukine-17 (IL-17) levels. Epigallocatechin-3-gallate (EGCG) specifically inhibits IFN-γ pathways and unlike Janus Kinase 1 and 2 (JAK1/JAK2) inhibitors (tofacit...

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Detalhes bibliográficos
Publicado no:Int J Environ Res Public Health
Main Authors: Hamed, Fatma N., McDonagh, Andrew J. G., Almaghrabi, Sarah, Bakri, Youssef, Messenger, Andrew G., Tazi-Ahnini, Rachid
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6313664/
https://ncbi.nlm.nih.gov/pubmed/30558329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijerph15122882
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