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Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM
The synthesis and evaluation of two classes of inhibitors for SgTAM, a 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are described. A mechanism-based strategy was used to design analogs that mimic the substrate or product of the reaction and form covalent interactions with the...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6312385/ https://ncbi.nlm.nih.gov/pubmed/18078753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.11.046 |
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