Anti-CD137 monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression

Because human epidermal growth factor-like receptor (HER) 2 is expressed on the surface of human pancreatic carcinoma cells to varying degrees, trastuzumab, an anti-HER2 monoclonal antibody (mAb), is expected to exert antibody-dependent, natural killer (NK) cell-mediated cytotoxicity (ADCC) against...

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Publicado en:PLoS One
Main Authors: Masu, Takushi, Atsukawa, Masanori, Nakatsuka, Katsuhisa, Shimizu, Masumi, Miura, Daishu, Arai, Taeang, Harimoto, Hirotomo, Kondo, Chisa, Kaneko, Keiko, Futagami, Seiji, Kawamoto, Chiaki, Takahashi, Hidemi, Iwakiri, Katsuhiko
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312288/
https://ncbi.nlm.nih.gov/pubmed/30596643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200664
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