Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections

[Image: see text] Systemic administration of antibiotics can cause severe side-effects such as liver and kidney toxicity, destruction of healthy gut bacteria, as well as multidrug resistance. Here, we present a bio-orthogonal chemistry-based strategy toward local prodrug concentration and activation...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Czuban, Magdalena, Srinivasan, Sangeetha, Yee, Nathan A., Agustin, Edgar, Koliszak, Anna, Miller, Ethan, Khan, Irfan, Quinones, Ilenis, Noory, Hasina, Motola, Christopher, Volkmer, Rudolf, Di Luca, Mariagrazia, Trampuz, Andrej, Royzen, Maksim, Mejia Oneto, Jose M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311693/
https://ncbi.nlm.nih.gov/pubmed/30648146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00344
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