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Rapid and Modular Assembly of Click Substrates To Assay Enzyme Activity in the Newborn Screening of Lysosomal Storage Disorders

[Image: see text] Synthetic substrates play a pivotal role in the development of enzyme assays for medical diagnostics. However, the preparation of these chemical tools often requires multistep synthetic procedures complicating structural optimization and limiting versatility. In particular, substra...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Principais autores: Skrinjar, Philipp, Schwarz, Markus, Lexmüller, Stefan, Mechtler, Thomas P., Zeyda, Maximilian, Greber-Platzer, Susanne, Trometer, Joe, Kasper, David C., Mikula, Hannes
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311692/
https://ncbi.nlm.nih.gov/pubmed/30648152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00668
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