Altered Synaptic Vesicle Release and Ca(2+) Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington’s Disease

Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the huntingtin (HTT) gene, which leads to progressive loss of neurons starting in the striatum and cortex. One possible mechanism for this selective loss of neurons in the early st...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Chen, Sidong, Yu, Chenglong, Rong, Li, Li, Chun Hei, Qin, Xianan, Ryu, Hoon, Park, Hyokeun
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311661/
https://ncbi.nlm.nih.gov/pubmed/30618623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00478
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