Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA**

Sustained identification of innovative chemical entities is key for the success of chemical biology and drug discovery. We report the fragment-based, computer-assisted de novo design of a small molecule inhibiting Helicobacter pylori HtrA protease. Molecular binding of the designed compound to HtrA...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Perna, Anna M., Rodrigues, Tiago, Schmidt, Thomas P., Böhm, Manja, Stutz, Katharina, Reker, Daniel, Pfeiffer, Bernhard, Altmann, Karl-Heinz, Backert, Steffen, Wessler, Silja, Schneider, Gisbert
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311382/
https://ncbi.nlm.nih.gov/pubmed/26069090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201504035
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