Different mutational rates and mechanisms in human cells at pre-gastrulation and neurogenesis

Somatic mosaicism in the human brain may alter function of individual neurons. We analyzed genomes of single cells from the forebrains of three human fetuses (15 to 21 weeks post-conception) using clonal cell populations. We detected 200–400 single nucleotide variations (SNVs) per cell. SNV patterns...

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Publicado en:Science
Main Authors: Bae, Taejeong, Tomasini, Livia, Mariani, Jessica, Zhou, Bo, Roychowdhury, Tanmoy, Franjic, Daniel, Pletikos, Mihovil, Pattni, Reenal, Chen, Bo-Juen, Venturini, Elisa, Riley-Gillis, Bridget, Sestan, Nenad, Urban, Alexander E, Abyzov, Alexej, Vaccarino, Flora M
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311130/
https://ncbi.nlm.nih.gov/pubmed/29217587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan8690
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