Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration

BACKGROUND: Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and cell death. To date, the multifunctional, autophagy-related...

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Detalles Bibliográficos
Publicado en:Mol Neurodegener
Main Authors: Bieri, Gregor, Lucin, Kurt M., O’Brien, Caitlin E., Zhang, Hui, Villeda, Saul A., Wyss-Coray, Tony
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310967/
https://ncbi.nlm.nih.gov/pubmed/30594228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0302-4
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