Yeast require redox switching in DNA primase

Eukaryotic DNA primases contain a [4Fe4S] cluster in the C-terminal domain of the p58 subunit (p58C) that affects substrate affinity but is not required for catalysis. We show that, in yeast primase, the cluster serves as a DNA-mediated redox switch governing DNA binding, just as in human primase. D...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: O’Brien, Elizabeth, Salay, Lauren E., Epum, Esther A., Friedman, Katherine L., Chazin, Walter J., Barton, Jacqueline K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310810/
https://ncbi.nlm.nih.gov/pubmed/30541886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810715115
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