Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy

Transforming growth factor (TGF)-α1 (encoded by TGFB1) is the prototypic member of the TGF-β family of 33 proteins that orchestrate embryogenesis, development and tissue homeostasis(1,2). Following its discovery(3), enormous interest and numerous controversies have emerged about the role of TGF-β in...

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Pubblicato in:Nat Genet
Autori principali: Kotlarz, Daniel, Marquardt, Benjamin, Barøy, Tuva, Lee, Way S., Konnikova, Liza, Hollizeck, Sebastian, Magg, Thomas, Lehle, Anna S., Walz, Christoph, Borggraefe, Ingo, Hauck, Fabian, Bufler, Philip, Conca, Raffaele, Wall, Sarah M., Schumacher, Eva M., Misceo, Doriana, Frengen, Eirik, Bentsen, Beint S., Uhlig, Holm H., Hopfner, Karl-Peter, Muise, Aleixo M., Snapper, Scott B., Strømme, Petter, Klein, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309869/
https://ncbi.nlm.nih.gov/pubmed/29483653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0063-6
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